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Today! COVID-19: The New Orleans Experience

Friday, May 1, 2020 – 2:00pm to 4:00pm

Featured Headlines

COVID-19 clotting and therapeutic anticoagulation – FLARE

The FLARE team discuss the increased activation of the coagulation cascade and reduced fibrinolytic activity in ARDS, therapeutic anticoagulation, and guideline data strategies.

[Opinion] Will Warm Weather Slow Coronavirus? – NYT/John Barry

Will there be another wave of Covid-19? And if so, how big will it be, and will there be more waves after it? The answer to those questions depend on seasonality, the susceptibility of the population to the disease, the rate at which the coronavirus mutates and how we come out of lockdown.

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) – Science

The virus causing coronavirus disease 2019 (COVID-19) has now become pandemic. How has it managed to spread from China to all around the world within 3 to 4 months? Li et al. used multiple sources to infer the proportion of early infections that went undetected and their contribution to virus spread.

The effect of human mobility and control measures on the COVID-19 epidemic in China – Science

What sort of measures are required to contain the spread of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19)? The rich data from the Open COVID-19 Data Working Group include the dates when people first reported symptoms, not just a positive test date. Using these data and real-time travel data from the internet services company Baidu, Kraemer et al. found that mobility statistics offered a precise record of the spread of SARS-CoV-2 among the cities of China at the start of 2020. The frequency of introductions from Wuhan were predictive of the size of the epidemic sparked in other provinces.

Cytokine release syndrome in severe COVID-19 – Science

n December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along with SARS-CoV and Middle East respiratory syndrome–coronavirus (MERS-CoV), SARS-CoV-2 is the third coronavirus to cause severe respiratory illness in humans, called coronavirus disease 2019 (COVID-19). This was recognized as a pandemic by the World Health Organization (WHO) in March 2020 and has had considerable global economic and health impacts. Although the situation is rapidly evolving, severe disease manifested by fever and pneumonia, leading to acute respiratory distress syndrome (ARDS), has been described in up to 20% of COVID-19 cases. This is reminiscent of cytokine release syndrome (CRS)–induced ARDS and secondary hemophagocytic lymphohistiocytosis (sHLH) observed in patients with SARS-CoV and MERS-CoV as well as in leukemia patients receiving engineered T cell therapy. Given this experience, urgently needed therapeutics based on suppressing CRS, such as tocilizumab, have entered clinical trials to treat COVID-19.

Coronavirus SARS-CoV-2 infects cells of the intestine – Eureka Alert

Researchers from the Hubrecht Institute in Utrecht, Erasmus MC University Medical Center Rotterdam, and Maastricht University in the Netherlands have found that the coronavirus SARS-CoV-2, which causes COVID-19, can infect cells of the intestine and multiply there. [Related Study in Science]

Russia’s Prime Minister Says He Has Coronavirus, As Country Tops 100,000 Cases – NPR

Russian Prime Minister Mikhail Mishustin says he’s infected with the novel coronavirus, joining nearly 106,500 others in the country who have been similarly diagnosed.

Speaking during a video conference with President Vladimir Putin that was broadcast Thursday on state-run Rossiya 24 television, Mishustin — who took over as prime minister from Dmitry Medvedev in January — told Putin that he had tested positive for the virus.