Members of the U.S. military who were vaccinated against COVID-19 showed higher-than-expected rates of heart inflammation, although the condition was still extremely rare, according to a study released on Tuesday.
Knowing which signatures in the blood predict protection against COVID-19 could speed the development of new vaccines. Researchers developing the Oxford–AstraZeneca COVID-19 vaccine have identified biomarkers that can help to predict whether someone will be protected by the jab they receive.
Immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a vital issue for global society. Determining the quality and duration of that immunity is therefore key. But the adaptive immune system is complex, and these factors may differ between natural immunity (obtained by infection) and vaccine-generated immunity (1). Additionally, there is the question of the combination: What kind of immunity develops in people with natural immunity who are subsequently vaccinated? Such “hybrid immunity” is particularly interesting because of the notable finding that people with previous SARS-CoV-2 infection mount unusually potent immune responses to COVID-19 vaccines (2). This is exemplified in two studies in this issue on pages 1413 and 1418 by Stamatatos et al. (3) and Reynolds et al. (4), respectively, which also highlight natural and vaccine-induced immune responses to variants.
More than 90 countries are using Covid shots from China. Experts say recent infections in those places should serve as a cautionary tale in the global effort to fight the disease.
The vaccine also produced long-lasting immune responses, researchers said. Booster shots seem unnecessary, at least for now.
Hospitalization rates for children with newly diagnosed type 2 diabetes rose sharply during the pandemic, two hospitals reported at the American Diabetes Association Scientific Sessions, held virtually this year. At Our Lady of the Lake Children’s Hospital in Baton Rouge, Louisiana, children with newly diagnosed type 2 diabetes accounted for 0.62% of inpatients from March through December 2020, up from 0.27% the year before.
Official Reporting for July 1, 2021
World Health Organization
Confirmed Cases: 182,101,209
Confirmed Cases: 182,685,990
Total cases: 33,496,454 (+14,256 New Cases)
Total deaths: 602,401 (+231 New Deaths)
Science and Tech
Researchers found that the treatment, a type of testosterone-blocker, also reduced the ability of the SARS-CoV-2 coronavirus to infect lung cells in the lab.
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based mRNA vaccine or convalescent individuals exhibited neutralizing titers, which were reduced 2-3.5 fold against the B.1.427/B.1.429 variant relative to wildtype pseudoviruses. The L452R mutation reduced neutralizing activity of 14 out of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 out of 10 NTD-specific mAbs since the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and formation of a new disulphide bond, as revealed by mass spectrometry and structural studies.
Avalon GloboCare, a leading biotechnology company focusing on cell-based technology and therapeutics, is about to launch clinical trials of its novel blood filtration system to mitigate symptoms of a cytokine storm in COVID-19 patients and a mucosal intranasal spray vaccination against SARS-CoV-2.
Researchers at MIT and Harvard University have designed a new face mask that can diagnose if the wearer is infected with SARS-CoV-2, the virus which causes COVID-19, within 90 minutes. The mask design, described in the journal Nature Biotechnology, has embedded tiny, disposable sensors that can be fitted into other face masks, and could also be adapted to detect other viruses.
Psychological and Sociological Impact
une has been a tumultuous month after a very tough year for Bridget Moore, who has just been discharged from a treatment facility for the eating disorder anorexia.
Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysis – PLoS
Misinformation, Disinformation, and Conspiracy Theories
than Lindenberger never got vaccinated as a kid. So one day, he went on Reddit and asked a simple question: “Where do I go to get vaccinated?” The post went viral, landing Lindenberger in the middle of a heated debate about vaccination and, ultimately, in front of a US Senate committee. Less than a year later, the high school senior reports back on his unexpected time in the spotlight and a new movement he’s leading to fight misinformation and advocate for scientific truth.
Their “Love in the Time of Covid” cards in each save-the-date envelope spelled it out clearly: This October wedding would be a vaccinated-only event. After all, the groom’s father, who is vaccinated against covid-19 but immunocompromised, needed to be sure he could safely attend.
Coping in 2020 (and probably most of 2021)