Tulane Outbreak Daily | May 11, 2020

Featured Headlines

Majority Black Counties See Triple the Covid Death Rate – Bloomberg

It has become increasingly clear that black Americans are dying at alarmingly high rates of Covid-19. But absent national statistics, the picture remains incomplete. Piecemeal data trickling out of cities and states have shown disproportionate death rates among African Americans, with an analysis of available state-provided figures by APM Research Lab putting the black death rate at 2.6 times higher than that of whites.

San Francisco Bay Area baby’s case may be first that links COVID-19 to Kawasaki disease – San Francisco Chronicle

Dr. Veena Jones was on her morning commute from her home in Menlo Park to her office at Lucile Packard Children’s Hospital in Palo Alto when she learned of lab test results that might have caused her to swerve off on El Camino Real if she hadn’t already been driving cautiously in the slow lane. [Related pre-print Paper]

Coronavirus blood-clot mystery intensifies – Nature

Research begins to pick apart the mechanisms behind a deadly COVID-19 complication.

Kawasaki Disease From COVID-19 in Kids: How Common? – Med Page Today

The first known published case of classic Kawasaki disease associated with COVID-19 was reported in Hospital Pediatrics in late April. A 6-month-old seen in Stanford, California, screened positive for COVID-19 after presenting with fever, blotchy rash, and minimal respiratory symptoms. She had initially been sent home from urgent care.

New articles from the Flare team:

  1. ECMO for COVID-19 (Part II)
  2. ECMO for COVID-19 (Part I)
  3. New observational reports on anticoagulation and immunomodulation
  4. Helmet ventilation in COVID-19

Warnings out on inflammatory syndrome but many questions remain

Market For Blood Plasma From COVID-19 Survivors Heats Up – NPR

Diana Berrent learned she had tested positive for COVID-19 on a Wednesday in mid-March. Within a day, she had received 30 emails from people urging her to donate blood.

Doctors keep discovering new ways the coronavirus attacks the body

Damage to the kidneys, heart, brain — even ‘covid toes’ — prompts reassessment of the disease and how to treat it

What We Don’t Know About Coronavirus Origins Might Kill Us – Bloomberg

The WHO is seeking a new mission to China to hunt for the pathogen’s source.

Nitric Oxide, BCG, and COVID-19’s Weakness – Med Page Today

While our attention is focused on the re-purposing of approved drugs to treat COVID-19 and to develop a durable vaccine to safeguard against SARS-CoV-2, the clinical outcomes of inhaled nitric oxide gas and BCG immunotherapy will likely emerge to be effective and provide insight as to coronavirus’ vulnerability: nitric oxide sensitivity.

Should We Worry That COVID-19 Coronavirus Is Sexually Transmitted? – Forbes

When it comes to outcomes in the disease process of coronavirus infections, men have been faring worse than women from the get-go. In the very early days of this virus’s presence in Wuhan, China, my Forbes piece reported that the death rate in males was nearly double that of females.

A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – NYT

A combination of three antiviral drugs, including interferon, seemed to speed recovery, researchers reported. [Related Lancet study]


Editor’s note: Regarding the case counts below, please consider due to limited testing capabilities in some locations, the real number of cases could be considerably higher.

Official Reporting for May 11, 2020

WHO SITREP #112 ECDC Johns Hopkins
Confirmed Cases 4,006,257 4,063,525 4,152,670
Deaths 278,892 282,244 284,536


Total cases: 1,300,696
Total deaths: 78,771
(Numbers close out at 4 p.m. the day before reporting.)

Surveillance Headlines


USA: For Most States, At Least A Third Of COVID-19 Deaths Are In Long-Term Care Facilities – NPR

New York: N.Y.C. Reports 38 Cases of Virus-Related Syndrome in Children – NYT


Mexico Sees Spike in Coronavirus Cases with 3,500 New Cases Over the Weekend


UK: Britain to Impose Quarantine on Air Travelers to Fight Coronavirus – NYT

Germany: Germany infection rate rises as lockdown eases – BBC

France: Eases lockdown after eight weeks – BBC


North Korea: Outbreak on Border Raises Doubts Over Its Virus Toll – Bloomberg

Wuhan, China: Wuhan in first virus cluster since end of lockdown – BBC

South Korea: As South Korea Eases Limits, Virus Cluster Prompts Seoul to Close Bars – NYT

Science and Tech

Supercomputer Simulations Identify Several Drugs as Potential Candidates Against COVID-19 – SciTechDaily

Several drugs approved for treating hepatitis C viral infection were identified as potential candidates against COVID-19, the disease caused by the SARS-CoV-2 coronavirus. This is the result of research based on extensive calculations using the MOGON II supercomputer at Johannes Gutenberg University Mainz (JGU). One of the most powerful computers in the world, MOGON II is operated by JGU and the Helmholtz Institute Mainz.


How remdesivir blocks SARS-CoV-2’s polymerase – Chemical and Engineering News

Researchers use cryo-EM to show how the drug stops RNA replication


NIH clinical trial testing antiviral remdesivir plus anti-inflammatory drug baricitinib for COVID-19 begins – NIH

A randomized, controlled clinical trial evaluating the safety and efficacy of a treatment regimen of the investigational antiviral remdesivir plus the anti-inflammatory drug baricitinib for coronavirus disease 2019 (COVID-19) has begun. The trial is now enrolling hospitalized adults with COVID-19 in the United States. The trial is expected to open at approximately 100 U.S. and international sites. Investigators currently anticipate enrolling more than 1,000 participants. National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is sponsoring the trial.

Study finds no hydroxychloroquine effect on death, severe COVID-19 – CIDRAP

large study on the use of the antimalaria drug hydroxychloroquine in hospitalized COVID-19 patients found that the drug had no impact on the risk of the most severe outcomes from the disease [Related Study NEJM]

A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – NYT

A combination of three antiviral drugs, including interferon, seemed to speed recovery, researchers reported. [Related Lancet study]


Economic Impact

Pandemic sends US jobless rate to 14.7% – BBC

The rise means the jobless rate is now worse than at any time since the Great Depression of the 1930s. Since the pandemic began, the US has suffered its worst growth numbers in a decade and the worst retail sales report on record.

Published Research

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – NEJM

Collateral Effect of Covid-19 on Stroke Evaluation in the United States – NEJM

Pre-Pub (not yet peer reviewed, should not be regarded as conclusive)


Coping in Quarantine

The Tulane Outbreak Daily (TOD) has had a few unsubscribes lately with the reasons being given are something like the following, “too depressing’, “I can’t deal with this anymore” and so on… In this section of the TOD going forward it will be dedicated to Mental Health Monday. Please feel free to email me content that you run across if it would benefit other readers. It appears this may go on for some time – let’s help lift each other up and come out the other end of this uncertain time better humans.

The coronavirus pandemic is pushing America into a mental-health crisis – Washington Post

Anxiety and depression are rising.

A guide to negotiating a covid “bubble” with other people – MIT Tech Review

Planning to widen your social circle to stop yourself going stir crazy? Here’s how to have the conversation.

This course will train an army of contact tracers. You can take it, too. – Washington Post

[Video at the link] The nation needs a sprawling network of contact tracers to track and halt the spread of covid-19, the disease caused by the novel coronavirus. Public health experts estimate that an effective tracking system will require at least 15 tracers per 100,000 Americans — and, in the hardest-hit regions, a workforce twice that size. [Link to register for course]