The Centers for Disease Control and Prevention released a set of documents on Thursday designed to provide guidance on how child care centers, schools, restaurants and bars, and other establishments could begin the process of reopening in the face of the coronavirus. The direction comes after calls from lawmakers and state officials mounted for the CDC to weigh in on how regions should reopen their economies. CDC Documents: Workplace, Child Care Centers, Schools, Restaurants and Bars, Youth Camps, Mass Transit
Covid-19 is primarily a respiratory infection that attacks the lungs, making it harder for patients to breathe and get enough oxygen to the rest of the body. Pneumonia and other respiratory conditions can quickly set in, eventually leading to death if the body cannot fight off the infection. But after over four months of cases, doctors are getting a more detailed look at some of the unexpected ways the virus hits the human body beyond the nasal cavity, throat, and lungs. Here are a few new things we’ve learned in recent weeks:
People with COVID-19 often experience gastrointestinal symptoms. An analysis of abdominal scans suggests that blood clots in small arteries may starve bowel tissue of oxygen in the most severely ill patients. [Related study]
Doctors have reported a flurry of cases in Covid-19 patients — including a healthy 27-year-old emergency medical technician in Queens. After a month in the hospital, he is learning to walk again. [Pre-Print Paper]
For social distancing policies that lasted at least 16 to 20 days, the daily rate of infection dropped by more than 9 percentage points, according to the study. Policies lasting 15 days and less also saw declines in the daily infection rate, researchers found. Such social distancing measures, mandated by 95 percent of the country, include shelter-in-place orders, school closures, bans on large events and the closure of gyms, bars and restaurants.[Related Study]
Some of the largest and highest resolution images recorded of the SARS-CoV-2 virus, the cause of the Covid-19 pandemic, have been published online by scientists at the University of Dundee and the EMBL’s European Bioinformatics Institute (EMBL-EBI).
cientists in Spain are expecting to begin regularly analyzing sewage for traces of the coronavirus that causes COVID-19, The Scientist has learned. Pending budget approval from AXA or national funds in Spain, researchers will carry out the work for at least a whole year, having signed a special agreement with authorities in the Valencian Community, a region on Spain’s eastern coast that is home to nearly 5 million people.
The science of sewage surveillance could be deployed in countries across the world to help monitor the spread of national epidemics of COVID-19 while reducing the need for mass testing, scientists say.
New from the FLARE Team:
- Cats and bats and pangolins: the origin of SARS-CoV-2
- Mechanical Ventilation in the Era of COVID-19: An Ongoing Debate
- Can a CT Tell You How to Ventilate in COVID-19?
Thousands of droplets from the mouths of people who are talking loudly can stay in the air for between eight and 14 minutes before disappearing, according to a new study. The research, conducted by a team with the US National Institutes of Health and published in PNAS Wednesday, could have significant impact on our understanding of covid-19 transmission.
Grieving families, social distancing, economic disruption: In many respects, coronavirus has changed the world. But it also has exposed the startlingly consistent toll that catastrophe exacts from black communities. The old adage that “when white America catches a cold, black America gets pneumonia” has become a chilling reality. [Related data]
As governors across the country reopen their states’ economies, policymakers are relying on disease models for help in predicting where new coronavirus cases may surge as stay-at-home orders expire.
In the United States in recent weeks, temporary packing plant closures due to Covid-19 outbreaks among workers have caused widespread processing backlogs. Experts put the number of hogs ready for slaughter (but not able to be processed) at the end of April at 1 million. Many hogs had to be euthanised. In the state of Minnesota, reported AgWeek, a large site was created to receive thousands of dead hogs each day for composting.
Official Reporting for May 15, 2020
|WHO SITREP #115||ECDC||Johns Hopkins|
Total deaths: 83,947
Orange County, California: Reports its highest daily coronavirus case count – LA Times
Michigan: Reports more than 1,000 coronavirus cases in day for first time in 2 weeks – Detroit Free Press
Michigan: Inflammatory syndrome linked to COVID-19 sickens more than 20 Michigan kids – Local news
Texas: Coronavirus in Texas: State reports largest daily increases in cases and deaths – Texas Tribune
Russia: Why Moscow didn’t count 60% of suspected Covid-19 deaths – CNN
France: About 4.4% of French population had been infected with SARS-CoV-2, suggests study – Medical News
Italy: Kawasaki-like COVID-19 complication found in Italian kids – CIDRAP
Mexico:Plans To Reopen Even As Officials Say COVID-19 Cases Are Near Peak – NPR
China: COVID-19 Has Arrived In Rohingya Refugee Camps And Aid Workers Fear The Worst – NPR
Science and Tech
Using mass spectrometry, researchers have shown how human cells are changed by infection from SARS-CoV-2, allowing the team to identify drug targets to prevent viral reproduction. [Related Study]
The researchers from Cardiff University’s School of Medicine, along with the universities of Nottingham, Colorado, Ottawa, Barcelona and Cambridge’s Babraham Institute included virologists, lipid specialists, microbicide and healthcare experts, while industry partners provided global formulation information. [Related Paper]
Immune warriors known as T cells help us fight some viruses, but their importance for battling SARS-CoV-2, the virus that causes COVID-19, has been unclear. Now, two studies reveal infected people harbor T cells that target the virus—and may help them recover. Both studies also found some people never infected with SARS-CoV-2 have these cellular defenses, most likely because they were previously infected with other coronaviruses.
Different species are helping answer different questions about COVID-19 in humans in order to develop vaccines and treatments
Therapeutics company Sorrento has made what it believes cold be a breakthrough in potential treatment of SARS-CoV-2, the virus that leads to COVID-19. The company released details its preclinical research on Friday, announcing that it has found an antibody that provides “100% inhibition of SARS-CoV-2 virus infection of healthy cells after four days incubation.” These results are from a preclinical study that still has to undergo peer review, and in an in vitro laboratory study (meaning not in an actual human being) but still a promising development as the company continues to work on production of an antibody “cocktail” that could provide protection against SARS-CoV-2 even in case of mutations in the virus.
Doctors on the frontlines still lack a proven treatment for the disease as researchers race to develop a vaccine. No drug is approved by the Food and Drug Administration (FDA) for COVID-19, although dozens of candidates – including drugs used to treat rheumatoid arthritis, parasites, cancer, and HIV – have been proposed and many are currently in clinical trials.
In the face of an immense burden of disease and an unfathomable death toll from COVID-19, the world today has an intense need for hope. A degree of hope does come in some regions from diminishing numbers of cases, hospitalizations and deaths, caused by extreme restrictions on commerce, travel and social interaction.
Being immune was once a status symbol—and another way to segregate and divide humanity
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets – Nature
Rapid risk assessment: Paediatric inflammatory multisystem syndrome and SARS -CoV-2 infection in children – ECDC
Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection – Function
Assessment of Deaths From COVID-19 and From Seasonal Influenza – JAMA
Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data – BMJ
The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission – PNAS
Strong Social Distancing Measures In The United States Reduced The COVID-19 Growth Rate – Health Affairs
SARS-CoV-2 pandemic : Time to revive the cyclophilin inhibitor alisporivir – Clinical Infectious Diseases
Assessing risk factors for SARS-CoV-2 infection in patients presenting with symptoms in Shanghai, China: a multicentre, observational cohort study – The Lancet
Estimating the burden of SARS-CoV-2 in France – Science Magazine
Abdominal Imaging Findings in COVID-19: Preliminary Observations – Radiology
Pre-Pub (not yet peer reviewed, should not be regarded as conclusive)
Significant Relaxation of SARS-CoV-2-Targeted Non-Pharmaceutical Interventions Will Result in Profound Mortality: A New York State Modelling Study – MedRXiv
Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients – MedRxiv
Coping in Quarantine