Featured Headlines
NAS letter suggests ‘normal breathing’ can expel coronavirus – Science
On 31 March, University of California, San Diego, atmospheric chemist Kimberly Prather set off an online debate by saying people should stop surfing during the coronavirus outbreak. Her reasoning: Viruses can travel long distances if carried by wind. “I ignited a bomb,” Prather says, as commenters pushed back, pointing to official assurances that the novel coronavirus is transmitted only short distances in respiratory droplets from a sneeze or cough. [Related document/National Academies] [Related NEJM Study] [Related Pre-Pub study] [Related Pre-Pub Study]
False-negative COVID-19 test results may lead to false sense of security – Science Daily
A new article calls attention to the risk posed by overreliance on COVID-19 testing to make clinical and public health decisions. The sensitivity of reverse transcriptase-polymerase chain reaction (RT-PCR) testing and overall test performance characteristics have not been reported clearly or consistently in medical literature, the article says.
One Way to Potentially Track Covid-19? Sewage Surveillance – Wired
NASA SINNOTT-ARMSTRONG, A graduate student at Stanford, does not have much experience as a sewage courier—normally, they’re busy studying genetics. But as with many of us, the pandemic is upending routines. Since early March, Sinnott-Armstrong has been making the rounds of the Bay Area’s wastewater treatment plants, collecting samples that may offer clues to Covid-19’s spread around the region.
‘People just didn’t care’: How the Ruby Princess cruise ship became a deathtrap – Washington Post
A health questionnaire had to be completed for every passenger before they could board. As crew members sifted through piles of paper, they had to break the news to some international passengers that they would not get to see New Zealand’s fjords or mountains.
Who gets hospitalized for Covid-19? Report shows differences by race and sex – Stat News
An analysis published Wednesday by the Centers for Disease Control and Prevention includes hospitalization data from a surveillance network tracking Covid-19 in 14 states — covering roughly 10% of the U.S. population — including statistics by race and sex. Reports from a small number of cities and states have suggested that the new disease is affecting Black Americans especially hard, prompting doctors, lawyers, public health officials, and lawmakers to call for a national breakdown of cases by race and ethnicity so that medical care can be matched to the greatest need. [Related CDC Report]
Iceland’s ‘Test Everyone’ Goal Has Skeptics, but It May Be Working – NYT
Critics say the Nordic island country should also have closed all of its schools and stopped tourism. But the government says it believes that new cases have peaked.
Why it’s too early to start giving out “immunity passports – MIT Technology Review
Coronavirus antibody testing needs to get a lot better, and so does our understanding of immunity, before people can start circulating freely.
How do SARS and MERS compare with COVID-19? – Medical News Today
While the world is firmly in the grip of the COVID-19 pandemic, we take a look back at SARS and MERS and their underlying pathogens, which are also coronaviruses.
Seven forms of coronavirus are known to affect humans. Four of them cause diseases similar to the common cold (229E, NL63, OC43 and HKU1) and the other three originated in animals and cause more severe diseases (SARS, MERS, and SARS-CoV-2).
The Institute of Human Virology (IHV) at the University of Maryland School of Medicine and scientists from Trieste, Italy announced today the characterization of a novel mutation in the RNA polymerase of certain viral strains of SARS-CoV-2 carried by patients located in Europe and North America. In addition, different patterns of mutations were identified in viral strains corresponding to different geographical areas. The data were obtained by analyzing more than 200 widespread full-length genomic sequences from the National Center for Biotechnology Information (NCBI) and the Global Initiative on Sharing All Influenza Data (GISAID) databases from December 2019 to March 2020. [Related Study]
Surveillance
Official Reporting for April 10, 2020
WHO SITREP #80 | ECDC | Country Data | Johns Hopkins | |
Confirmed Cases | 1,436,198 | 1,563,857 | 1,619,495 |
Deaths | 85,522 | 95,044 | 97,199 |
Total deaths: 14,696
Travel Related: 1,930
Close Contact: 9,763
Under Investigation: 415,767
Total Cases: 427,460
Surveillance Headlines
USA
New York: Has more cases than any country – BBC
Washington DC: What the first month tells us about its spread – Washington Post
LATIN AMERICA
EUROPE
Germany: Blood tests show 14% of people are now immune to covid-19 in one town in Germany – MIT Technology Review
UK: Prime Minister Boris Johnson Leaves ICU Amid Treatment For COVID-19 – NPR
Italy: Reported 4,202 new cases, up from 3,863 yesterday, along with 610 more deaths, up from 542 the previous day – CIDRAP.
Spain: Reported 683 deaths today, down from 757 the day before. – CIDRAP
Belgium and Netherlands: Each country again reporting more than 1,000 new cases. The number of intensive care unit (ICU) patients is still increasing.
Turkey: Reported 4,056. The country has curfews in place for people under 20 and those over age 65, and the country’s health minister said most of the new cases are in people ages 20 to 65. CIDRAP
Russia: Reported 1,459 new cases, totaling 10,131. The “non-working week” measure has been extended until Apr 30 to slow the spread of the virus. CIDRAP
ASIA
Indonesia: Reported 40 more deaths and 337 new cases. CIDRAP
Singapore: Battling a second wave of infections—reported its biggest 1-day jump today with 287 new cases. CIDRAP
Japan: Reports Tokyo had the record high of 181 cases. CIDRAP
Science and Tech
New coronavirus (SARS-CoV-2) mapped out – Eureka Alert
Jean and Peter Medawar wrote in 1977 that a virus is “simply a piece of bad news wrapped up in proteins.” The “bad news” in the SARS-CoV-2 case is the new coronavirus carries its mysterious genome in the form of a very long ribonucleic acid (RNA) molecule. Grappling with COVID-19 pandemic, the world seems to be lost with no sense of direction in uncovering what this coronavirus (SARS-Cov-2) is composed of.
Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein – The Scientist
The virus’s tool for prying open host cells is coated in a protective armor of sugar—but gaps may offer vulnerability to disruption by antibodies.
Nearly 20 years ago, when a different coronavirus struck, Michael Farzan and his team figured out how it was getting into human cells: targeting a specific receptor called ACE2 found on certain cells.
Clinical Trials
A Review of SARS-CoV-2 and the Ongoing Clinical Trials – International Journal of Molecular Sciences
Vaccine
If a coronavirus vaccine arrives, can the world make enough? – Nature
Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.
Diagnostics
Germany to run Europe’s first large-scale antibody test programme – Financial Times
Published Research
Neurotropism of SARS-CoV 2: Mechanisms and manifestations – Journal of the Neurological Sciences
Dysregulation of lung myeloid cells in COVID-19 – Nature
Fighting COVID-19 exhausts T cells – Nature
In the eye of the COVID-19 cytokine storm – Nature
Cardiopulmonary resuscitation after hospital admission with covid-19 – BMJ
Covid-19 in South Korea — Challenges of Subclinical Manifestations – NEJM
Infection Prevention
Food Safety and COVID-19 – JAMA
New Sources Available on Obtaining PPE Supplies – Provider Magazine
The American Health Care Association/National Center for Assisted Living (AHCA/NCAL) on Thursday said while obtaining personal protective equipment (PPE) continues to be a challenge for long term care (LTC) providers in many parts of the country, there are new sources to tap to possibly obtain needed supplies as the COVD-19 pandemic continues.
Economic Impact
COVID-19 and the Economy – Federal Reserve
COVID-19 (Coronavirus) Drives Sub-Saharan Africa Toward First Recession in 25 Years – World Bank
Growth in Sub-Saharan Africa has been significantly impacted by the ongoing coronavirus outbreak and is forecast to fall sharply from 2.4% in 2019 to -2.1 to -5.1% in 2020, the first recession in the region over the past 25 years, according to the latest Africa’s Pulse, the World Bank’s twice-yearly economic update for the region.
Post Pandemic
Life After COVID-19: Letter From Beijing – New York Magazine
Coping in Quarantine
Recipe from the Quarantine Kitchen – Youtube