COVID-19 can ravage the body, targeting the lungs, heart and blood vessels. To curb this wide-ranging attack, scientists are focusing on another part of the body: the nose.
Months after infection with SARS-CoV-2, some people are still battling crushing fatigue, lung damage and other symptoms of ‘long COVID’.
Experts worry that the two diseases could overwhelm the health care system and create a new shortage of hospital beds and personal protective equipment.
A National Institutes of Health-funded study found that people with substance use disorders (SUDs) are more susceptible to COVID-19 and its complications. The research, published today in Molecular Psychiatry, was co-authored by Nora D. Volkow, M.D., director of the National Institute on Drug Abuse (NIDA). The findings suggest that health care providers should closely monitor patients with SUDs and develop action plans to help shield them from infection and severe outcomes.
Agi Hajduczki, a research scientist at the Walter Reed Army Institute of Infectious Diseases, opens a large freezer and takes out boxes of DNA. She is part of a team making a COVID-19 vaccine.
As we learn more about transmission of SARS-CoV-2, the news for restaurants goes from bad to worse. And while there’s a long list of sad things about this pandemic, the decimation of the restaurant business for owners and the people who work there is right up there. The loss of the restaurant experience for us diners is pretty sad, too.
t has been over nine months since STAT published reporter Helen Branswell’s first article about a mysterious cluster of pneumonia-like cases in the Chinese city of Wuhan. The cause of those infections was, of course, a new coronavirus called SARS-CoV-2. That virus and the disease it causes, Covid-19, have since become the biggest story in the world.
Coronavirus cases continued to grow over the weekend in nearly a dozen U.S. states as Dr. Anthony Fauci, the nation’s leading infectious disease expert, warns about the nation’s worrying level of new infections.
Researchers randomly surveyed more than 1,000 people from across Maryland, asking about their social distancing practices and how often they head out of the house.
Here we report a case study of a SARS-CoV-2 outbreak event during bus trips of an index patient in Hunan Province, China. This retrospective investigation suggests potential airborne transmission of SARS-CoV-2 and the possibility of superspreading events in certain close contact and closed space settings, which should be taken in to account when control strategies are planned.
Two new studies involving evolutionary genomics, computer simulations, and travel records from the COVID-19 pandemic suggest that inadequate travel monitoring, contact tracing, and community surveillance allowed the novel coronavirus to spread unchecked to and throughout North America and Europe in late January or early February.
As many as 40% of patients admitted to hospital with COVID-19 have acute kidney injury. Acute kidney injury (AKI) is a common complication of coronavirus disease 2019 (COVID-19) and is usually related to disease severity.
Internet searches on gastrointestinal symptoms predicted a rise in Covid-19 cases weeks later, researchers at Massachusetts General Hospital found, demonstrating a novel early warning system for hot spots of the pandemic disease.
A small number of COVID-19 patients have survived after getting a double-lung transplant. One of those patients, Mayra Ramirez, shares the story of her surgery and ongoing recovery.
Official Reporting for September 14, 2020
Cumulative Cases: 28,918,900
Cumulative Deaths: 922,252
Confirmed Cases: 29,049,134
Confirmed Cases: 29,136,553
Total deaths: 193,705
Wisconsin: Wisconsin reports its record number of new daily cases, with spikes linked to college campuses – NY Times
Midwest: A record surge in new cases has hit the Midwest. – New York Times
France: Cases in France leap past 10,000 a day – BBC
Israel: To impose three-week national lockdown – BBC
India: At Least 25 Indian Lawmakers Test Positive For Coronavirus As Parliament Reopens – NPR
Science and Tech
The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein – University of Oxford Immunology Network
Boson et al. characterised how the intracellular trafficking and maturation of the SARS-CoV-2 S protein are regulated by the other structural proteins E, M and N. Co-expression of E or M were found to decrease S cleavage, alter the N-glycosylation patterns in the S2 subunit and to retain S protein in the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) or cis-Golgi, known CoV assembly sites. The S protein expressed alone was found widely distributed within the cell and to promote syncytia, which was prevented with SARS-CoV-2 infection or co-expression with E or M. In contrast, N protein does not appear to have any effect on S maturation or localisation. While E protein was found to influence the level of S expression by inducing a non-specific retention of glycoproteins in the ER and to slow down the cell secretory pathway; M influenced S localisation through direct interaction with S C-terminal moiety. Finally, all structural proteins proved essential for VLP formation.
Community and close contact exposures continue to drive the coronavirus disease 2019 (COVID-19) pandemic. CDC and other public health authorities recommend community mitigation strategies to reduce transmission of SARS-CoV-2, the virus that causes COVID-19 (1,2). Characterization of community exposures can be difficult to assess when widespread transmission is occurring, especially from asymptomatic persons within inherently interconnected communities.
Pfizer Inc. Chief Executive Officer Albert Bourla said it’s “likely” the U.S. will deploy a Covid-19 vaccine to the public before year-end and that the company is prepared for that scenario, pushing back against more tepid expectations shared by health authorities.
Social and Psychological Impact
5 min audio at the link – NPR’s Lulu Garcia-Navarro talks to actor Alan Alda, who started a center focused on communicating scientific information to the public, on how the dearth of empathy is affecting pandemic messaging.
Psychiatric presentation of patients with acute SARS-CoV-2 infection: a retrospective review of 50 consecutive patients seen by a consultation-liaison psychiatry team. – Physicians Weekly
SARS-CoV-2 transmission via speech-generated respiratory droplets – The Lancet
Coping in Quarantine
We had a special guest stay at our B&B last weekend. Her name is Pia, and she is an award winning poet who needed a quiet place to finish her latest book of poetry. She was in luck, she had the place to herself for the first part of the weekend, and she finished her book. We shared some conversation and French wine one evening. What an amazing, warm, talented human. She sent her manuscript and I read a few of her poems this morning with a cup of coffee. Mind = blown. They are just words on a screen, configured in such a way upon reading, that the imagination is sparked and mind transported. I started wondering if there was a collection of poetry inspired by this global pandemic. The internet did not disappoint… there are many. This is just one.