Despite the 95 percent effectiveness at preventing coronavirus infection after two doses of its vaccine, Pfizer is now seeing what a third dose might do.
Pfizer/BioNTech’s COVID-19 vaccine appeared to prevent not only symptomatic disease, but asymptomatic infection as well, a real-world review of Israeli health records showed.
“We are working quite hard on this and trying to convince people to accept the vaccine and really to rebuild the trust in the vaccine,” one official said.
After this modified adenovirus is injected into someone’s arm, it enters the person’s cells. The cells then read the genetic instructions needed to make the spike protein and the vaccinated cells make and present the spike protein on their own surface. The person’s immune system then notices these foreign proteins and makes antibodies against them that will protect the person if they are ever exposed to SARS-CoV-2 in the future.
Dr. Anthony Fauci, the nation’s top infectious disease expert, is encouraging everyone to get the coronavirus vaccine as soon as it becomes available to them, and he answered questions about the vaccines from viewers as part of the CBSN special, “A Shot of Hope: Vaccine Questions Answered.”
GW will be a clinical trial site for Sanofi and GSK’s adjuvanted recombinant protein-based COVID-19 vaccine candidate
Today, the U.S. Food and Drug Administration announced that it is allowing undiluted frozen vials of the Pfizer-BioNTech COVID-19 Vaccine to be transported and stored at conventional temperatures commonly found in pharmaceutical freezers for a period of up to two weeks. This reflects an alternative to the preferred storage of the undiluted vials in an ultra-low temperature freezer between -80ºC to -60ºC (-112ºF to -76ºF). The change is being reflected in updates to the Fact Sheet for Healthcare Providers Administering Vaccine (Vaccination Providers).
The National Medical Products Administration gave conditional approval to a vaccine from CanSino Biologics and a second one from state-owned Sinopharm. Both are already being used among select groups of people under an emergency use authorization. China now has four vaccines to immunize its population.
How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk – JAMA
After grappling with the virus SARS-CoV-2 for more than a year, clinics still face the same reality they did months ago: There are no quick and easy fixes for treating COVID-19.
Official Reporting for February 26, 2021
World Health Organization
Confirmed Cases: 112 209 815
Deaths: 2 490 776
Confirmed Cases: 112,981,257
Total cases: 28,138,938 (+74,806 New Cases)
Total deaths: 503,587 (+2,407 New Deaths)
Science and Tech
In order to infect cells, SARS-CoV-2, the virus that causes COVID-19, needs to insert itself into the membrane of human cells. New molecular models show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in 2019, and its high pathogenicity, infectivity, and transmissibility have led to a global pandemic. Although several vaccines have been approved in different countries, most of the global population currently remains unvaccinated because of disparities in vaccine distribution and limited manufacturing capabilities (1). Owing to a lack of treatment options (particularly in low- and middle-income countries), the slow progression of vaccination, and the emergence of SARS-CoV-2 variants that elicit reduced responses to vaccines, there is an urgent need to identify therapeutics to reduce COVID-19 morbidity and mortality
SARS-CoV-2, the coronavirus that causes COVID-19, has devastated the human population, infecting over 110 million people and causing almost 2.5 million deaths to date. SARS-CoV-1 and SARS-CoV-2 both belong to the same coronavirus family. A key question is: What makes one more infectious than the other? The lab of or Dr Mahmoud Moradi at the University of Arkansas has used molecular simulations, performed at the Texas Advanced Computing Center and the Pittsburgh Supercomputing Center, to investigate this question.
Psychological and Sociological Impact
Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – NEJM
Suspected Recurrent SARS-CoV-2 Infections Among Residents of a Skilled Nursing Facility During a Second COVID-19 Outbreak — Kentucky, July–November 2020 – CDC
Assessment of SARS-CoV-2 infectivity of upper respiratory specimens from COVID-19 patients by virus isolation using VeroE6/TMPRSS2 cells – BMJ
SARS-CoV-2 Respiratory Co-Infections: Incidence of Viral and Bacterial Co-Pathogens – International Journal of Infectious Diseases
Misinformation, Disinformation, and Conspiracy Theories
While public health officials were urging Americans to take measures to help stop the coronavirus, high rates of infection within Black communities fueled his sister’s mistrust, said Hildreth, the president of Meharry Medical College, an historically Black institution in Nashville. She had no desire to be vaccinated, and thought officials wanted people like her — Black people — “to prove the vaccine is safe so others will take it.”
Coping in 2020 (and probably most of 2021)